We are sorry for the problems you have as we can not reproduce on our systems running Fall Creators Update.
This sounds like a permission issue, as side effect from the Windows Fall Creators Update.
Please un-install your Spyder software.
Afterwards delete the folder "Datacolor" from here:
C:\Program Files (x86)\
(the folder AppData may be hidden)
Now reboot your system.
Download and install with full admin rights and deactivated antivirus program the current version.
Sometimes you need to do a right mouse click -> run as admin instead of a double click to start an application with admin rights granted.
Activate with your license code.
Run the software also with full admin rights.
Keep the Spyder unplugged during un-install and re-install. Plug in the Spyder when prompted to do so. Please always plug the Spyder into an USB port in the back of your computer (close to the keyboard/mouse). Please do not use USB-Hubs and/or USB-extension cords as this could result into problems with the power supply.
Now, run a new calibration.